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KMID : 0984920160180020005
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Journal of Skin Barrier Research
2016 Volume.18 No. 2 p.5 ~ p.9
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Skin-Based Diabetes Monitoring and Control
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Kim Dae-Hyeong
Lee Hyun-Jae
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Abstract
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Diabetes is one of the most prevalent chronic diseases. Approximately 9% of world population have diabetes. Since diabetes can cause many complications, such as cardiovascular, kidney, and neural diseases, which increase the risk of death dramatically, precise monitoring and continuous treatment are greatly needed. According to the conventional treatment protocol, patients are required to take blood samples, analyze the glucose concentration using a test strip together with a stand-alone equipment, and then take an appropriate amount of insulin shots. However, this process is painful, and repetitive testing and shots cause huge stress. Therefore, patients become reluctant to follow the recommended testing frequency, which aggravates the diabetes symptoms and leads to such complications. The recent years have seen the emergence of wearable electronics and optoelectronics technologies, and these technological advances have opened up the possibility of realizing noninvasive diabetes control. In particular, wearable sweat-analysis devices have received great attention. Human sweat contains various physiological biomarkers including glucose. The glucose concentration in sweat has a good correlation with that in blood. Sweat-based glucose sensing is a painless and stress-free monitoring method. However, the requirements for achieving accurate sweat-based glucose sensing are different from those for blood-based sensing. Therefore, an entirely new integrated system of sensors and feedback transdermal drug delivery devices that eliminate pain and stress as well as consider different factors for accurate sensing should be developed. In this report, we introduce the development of skin-amounted graphene-hybrid device arrays capable of sweat-based glucose monitoring in conjunction with controlled transcutaneous drug delivery for non-invasive diabetes treatment.
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KEYWORD
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Flexible electronics, Biomedical devices, Wearable devices, Implantable devices, Minimally invasive surgical tools
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